U.S. actors Owen Wilson (L) and Vince Vaughn arrive for the world premiere of "Wedding Crasher" in Leicester Square in London July 4 2005. (FILE)

Wedding Crashers stars Owen Wilson and Vince Vaughn are set to reunite for a new work comedy.

The funnymen scored big laughs on the big screen when they teamed up for the 2005 movie, and now Vaughn has recruited his pal to star in his self-penned film Interns, about two middle-aged men who are laid off from their jobs and forced to start at the bottom of the career ladder all over again, reports NYMag.com's Vulture blog.

Wedding Crashers, which co-starred Rachel McAdams and Isla Fisher, grossed over $285 million worldwide.